The ADVANCE Study Design
The primary outcomes will be major macrovascular complications (stroke and heart attack) and major microvascular complications (eye and renal disease).
The study organisation structure is shown below. The Management Committee has overall scientific responsibility for the study, which is managed by an International Coordinating Centre in Sydney (The George Institute for Global Health), and five regional coordinating centres in Beijing, London, Melbourne, Montreal and Utrecht.
Each regional coordinating centre is responsible for the clinical sites within one or more countries.
The ADVANCE Study Committee